Article
Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.
The Journal of biological chemistry - 11 Oct 2002
Oshiro Takafumi, Koyama Shinya, Sugiyama Shinichiro, Kondo Akiko, Onodera Yasuhito, Asahara Toshimasa, Sabe Hisataka, Kikuchi Akira
Abstract excerpt
POB1 was previously identified as a RalBP1-binding protein. POB1 and RalBP1 function downstream of small G protein Ral and regulate receptor-mediated endocytosis. To look for additional functions of POB1, we screened for POB1-binding proteins using a yeast two-hybrid method and found that POB1 interacts with mouse ASAP1, which is a human PAG2 homolog. PAG2 is a paxillin-associated protein with ADP-ribosylation...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Motifs
- Animals
- Calcium-Binding Proteins
- Carrier Proteins
- Cell Line
- Cell Movement
- Cytoskeletal Proteins
- Focal Adhesions
- Fungal Proteins