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Article

The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism.

Journal of molecular cell biology - 1 Apr 2014

Zhang Hao, Chang Yu-Chung, Brennan Mark L, Wu Jinhua

Abstract excerpt

The small GTPase Rap1 induces integrin activation via an inside-out signaling pathway mediated by the Rap1-interacting adaptor molecule (RIAM). Blocking this pathway may suppress tumor metastasis and other diseases that are related to hyperactive integrins. However, the molecular basis for the specific recognition of RIAM by Rap1 remains largely unknown. Herein we present the crystal structure of an active,...

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Identifiers

PMID: 24287201
DOI: 10.1093/jmcb/mjt044
PMCID: PMC4817127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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