Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.

doi:10.1074/jbc.M800802200

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Article

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration.

The Journal of biological chemistry - 22 Aug 2008

Kiely Patrick A, Baillie George S, Lynch Martin J, Houslay Miles D, O'Connor Rosemary

Abstract excerpt

Insulin-like growth factor (IGF)-I regulates a mutually exclusive interaction of PP2A and beta1 integrin with the WD repeat scaffolding protein RACK1. This interaction is required for the integration of IGF-I receptor (IGF-IR) and adhesion signaling. Here we investigated the nature of the binding site for PP2A and beta1 integrin in RACK1. A WD7 deletion mutant of RACK1 did not associate with PP2A but retained...

Topics

Amino Acid Sequence
Binding, Competitive
Cell Line, Tumor
Cell Movement
Cell Proliferation
GTP-Binding Proteins
Gene Expression Regulation, Neoplastic
Humans
Insulin-Like Growth Factor I
Integrin beta1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Neoplasm Proteins

Protein Phosphatase 2

Receptors for Activated C Kinase

Receptors, Cell Surface

Recombinant Proteins

Tyrosine

Source

Open in PubMed

Identifiers

PMID: 18567578
DOI: 10.1074/jbc.M800802200

Genes

RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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