Article
Interaction characteristics of Plexin-B1 with Rho family proteins.
Biochemical and biophysical research communications - 17 May 2013
Fansa Eyad Kalawy, Dvorsky Radovan, Zhang Si-Cai, Fiegen Dennis, Ahmadian Mohammad Reza
Abstract excerpt
Plexin-B1 regulates various cellular processes interacting directly with several Rho proteins. Molecular details of these interactions are, however, not well understood. In this study, we examined in vitro and in silico the interaction of the Rho binding domain (B1RBD) of human Plexin-B1 with 11 different Rho proteins. We show that B1RBD binds in a GTP-dependent manner to Rac1, Rac2, Rac3, Rnd1, Rnd2, Rnd3, and...
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