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Article

Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma.

Leukemia & lymphoma - 1 May 2002

Lossos Izidore S, Thorstenson Yvonne R, Wayne Tierney L, Oefner Peter J, Levy Ronald, Chu Gilbert

Abstract excerpt

Loss of function of the ataxia-telangiectasia mutated (ATM) gene, located on human chromosome 11q22-23, is the cause of ataxia-telangiectasia (A-T), which is associated with an extremely high risk for lymphoma. Abnormalities in 11q22-23, including deletions and mutations of the ATM gene, have been reported in T-cell prolymphocytic leukemias, B-CLL and in mantle cell lymphoma. In a survey of gene expression in...

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Source

Identifiers

PMID: 12148890
DOI: 10.1080/10428190290021623

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma.PMID 12148890Read ↗

ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma.Semantic proximity Read ↗

Ataxia telangiectasia gene mutations in leukaemia and lymphoma.Semantic proximity Read ↗

Mantle cell lymphoma is characterized by inactivation of the ATM gene.Semantic proximity Read ↗

ATM mutations are rare in familial chronic lymphocytic leukemia.Semantic proximity Read ↗

Analysis of FAS (CD95) gene mutations in higher-grade transformation of follicle center lymphoma.Semantic proximity Read ↗

A systematic evaluation of the ataxia telangiectasia mutated gene does not show an association with non-Hodgkin lymphoma.Semantic proximity Read ↗

Biallelic mutations in the ATM gene in T-prolymphocytic leukemia.Semantic proximity Read ↗

ATM mutations in sporadic lymphoid tumours.Semantic proximity Read ↗

Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage.Semantic proximity Read ↗

ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalances.Semantic proximity Read ↗

ATM mutations and protein expression are not associated with familial B-CLL cases.Semantic proximity Read ↗

Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

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