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Article

Biallelic mutations in the ATM gene in T-prolymphocytic leukemia.

Nature medicine - 1 Oct 1997

Stilgenbauer S, Schaffner C, Litterst A, Liebisch P, Gilad S, Bar-Shira A, James M R, Lichter P, Döhner H

Abstract excerpt

Ataxia-telangiectasia (AT) is an autosomal recessive disorder characterized by cerebellar ataxia, oculocutaneous telangiectasia, immune deficiency, genome instability and predisposition to malignancies, particularly T-cell neoplasms. The responsible gene, designated ataxia-telangiectasia mutated (ATM), was recently identified by positional cloning in the chromosomal region 11q22.3-23.1 (ref. 4, 5) ATM is 150 kb...

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Source

Identifiers

PMID: 9334731
DOI: 10.1038/nm1097-1155

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Biallelic mutations in the ATM gene in T-prolymphocytic leukemia.PMID 9334731Read ↗

Inactivation of the ATM Gene in T-Cell Prolymphocytic LeukemiasSemantic proximity Read ↗

Inactivation of the ATM gene in T-cell prolymphocytic leukemias.Semantic proximity Read ↗

The ataxia telangiectasia gene in familial and sporadic cancer.Semantic proximity Read ↗

The ATM gene and susceptibility to childhood T-cell acute lymphoblastic leukaemia.Semantic proximity Read ↗

Ataxia telangiectasia gene mutations in leukaemia and lymphoma.Semantic proximity Read ↗

Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations.Semantic proximity Read ↗

Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia.Semantic proximity Read ↗

Ataxia-telangiectasia and T-cell leukemias: no evidence for somatic ATM mutation in sporadic T-ALL or for hypermethylation of the ATM-NPAT/E14 bidirectional promoter in T-PLL.Semantic proximity Read ↗

The genetic defect in ataxia-telangiectasia.Semantic proximity Read ↗

ATM mutations in sporadic lymphoid tumours.Semantic proximity Read ↗

Ataxia telangiectasia syndrome: moonlighting ATM.Semantic proximity Read ↗

A single ataxia telangiectasia gene with a product similar to PI-3 kinase.Semantic proximity Read ↗

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