Article
A systematic evaluation of the ataxia telangiectasia mutated gene does not show an association with non-Hodgkin lymphoma.
International journal of cancer - 1 Nov 2007
Sipahimalani Payal, Spinelli John J, MacArthur Amy C, Lai Agnes, Leach Stephen R, Janoo-Gilani Rozmin T, Palmquist Diana L, Connors Joseph M, Gascoyne Randy D, Gallagher Richard P, Brooks-Wilson Angela R
Abstract excerpt
The ataxia telangiectasia mutated (ATM) gene is critical for the detection and repair of DNA double-stranded breaks. Mutations in this gene cause the autosomal recessive syndrome ataxia telangiectasia (AT), an attribute of which is an increased risk of cancer, particularly lymphoma. We have undertaken a population-based case/control study to assess the influence of genetic variation in ATM on the risk of...
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