Article
ATM mutations are rare in familial chronic lymphocytic leukemia.
Blood - 15 Jul 2002
Yuille Martin R, Condie Alison, Hudson Chantelle D, Bradshaw Paul S, Stone Elaine M, Matutes Estella, Catovsky Daniel, Houlston Richard S
Abstract excerpt
It is now recognized that a subset of B-cell chronic lymphocytic leukemia (CLL) is familial. The genetic basis of familial CLL is poorly understood, but recently germ line mutations in the Ataxia Telangiectasia (ATM) gene have been proposed to confer susceptibility to CLL. The evidence for this notion is, however, not unequivocal. To examine this proposition further we have screened the ATM gene for mutations in...
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