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Article

ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma.

Blood - 15 Aug 2002

Grønbaek Kirsten, Worm Jesper, Ralfkiaer Elisabeth, Ahrenkiel Vibeke, Hokland Peter, Guldberg Per

Abstract excerpt

The ATM serine-threonine kinase plays a central role in the cellular response to DNA damage. Germ-line mutations in the ATM gene cause ataxia-telangiectasia (A-T), a multisystem disorder associated with predisposition to lymphoma and acute leukemia. Moreover, somatic ATM mutations have been identified in T-cell prolymphocytic leukemia, mantle cell lymphoma, and B-cell chronic lymphocytic leukemia. In this study,...

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Topics

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Share to Ataxia Telangiectasia Mutated Proteins
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Lymphoma, B-Cell

Share to Lymphoma, Large B-Cell, Diffuse

Share to Proto-Oncogene Proteins c-mdm2

Share to RNA Splicing

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 12149228
DOI: 10.1182/blood-2002-02-0382

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma.PMID 12149228Read ↗

Ataxia telangiectasia gene mutations in leukaemia and lymphoma.Semantic proximity Read ↗

Somatic ATM Mutations Indicate a Pathogenic Role of ATM in B-Cell Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

Ataxia-Telangiectasia Mutated (ATM) gene signaling pathways in human cancers and their therapeutic implications.Semantic proximity Read ↗

Biallelic mutations in the ATM gene in T-prolymphocytic leukemia.Semantic proximity Read ↗

ATM Mutations in Cancer: Therapeutic Implications.Semantic proximity Read ↗

ATM gene and lymphoid malignancies.Semantic proximity Read ↗

Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma.Semantic proximity Read ↗

Mantle cell lymphoma is characterized by inactivation of the ATM gene.Semantic proximity Read ↗

ATM mutations in sporadic lymphoid tumours.Semantic proximity Read ↗

ATM mutations in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

Rare germline variants in ATM are associated with chronic lymphocytic leukemia.Semantic proximity Read ↗

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