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Article

Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol.

Pharmacogenetics - 1 Jul 2002

Tanus-Santos Jose E, Desai Mehul, Deak Leslie R, Pezzullo John C, Abernethy Darrell R, Flockhart David A, Freedman Jane E

Abstract excerpt

Impaired platelet-derived nitric oxide (NO) contributes to acute coronary syndromes by enhancing platelet recruitment and thrombus formation. Polymorphic variants of the endothelial NO synthase (eNOS) gene have been associated with cardiovascular diseases. To examine whether eNOS variants affect platelet-derived NO and platelet function, and to assess the effects of estradiol on platelet function, we studied...

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Identifiers

PMID: 12142730
DOI: 10.1097/00008571-200207000-00008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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