Article
[Allelic polymorphism of endothelial NO-synthase gene and its functional activity].
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) - 1 Jan 2005
Dosenko V Ie, Zahoriĭ V Iu, Khaĭtovych N V, Hordok O A, Moĭbenko O O
Abstract excerpt
Investigation of phenotypic realization of the eNOS gene allelic polymorphism has shown that eNOS RNA content and eNOS activity in platelets depends on genotype. Using the reverse transcription and polymerase chain reaction it was shown that eNOS mRNA content is the lowest at -786C/C promoter's genotype. In exon 7 homozygotes (894T/T) the RNA level is lower than in normal homozygotes (894G/G), but it is higher...
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