Article
Allelic polymorphism of endothelial NO-synthase gene and its functional manifestations.
Acta biochimica Polonica - 1 Jan 2006
Dosenko Victor E, Zagoriy Vyacheslav Y, Haytovich Nikolay V, Gordok Olga A, Moibenko Alexey A
Abstract excerpt
Investigation of the mechanisms of phenotypic realization of allelic polymorphism of the eNOS gene has shown that the level of eNOS mRNA and activity of this enzyme in platelets depends from genotype. We identified a T(-786)-->C polymorphism in the promoter region, a variable number of tandem repeats (4a/4b) in intron 4 and the G(894)-->T polymorphism in exon 7 of the eNOS gene in isolated human platelets. We...
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