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Article

Endothelial nitric oxide synthase genotypes and haplotypes modify the responses to sildenafil in patients with erectile dysfunction.

The pharmacogenomics journal - 1 Apr 2013

Muniz J J, Lacchini R, Rinaldi T O, Nobre Y T D A, Cologna A J, Martins A C P, Tanus-Santos J E

Abstract excerpt

Erectile dysfunction (ED) is usually treated with sildenafil. Although genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may impair endogenous NO formation, there is little information about how eNOS polymorphisms and haplotypes affect the responses to sildenafil. We studied 118 patients; 63 patients had ED secondary to radical prostatectomy (PED) and 55 had organic, clinical ED. eNOS...

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Identifiers

PMID: 22064666
DOI: 10.1038/tpj.2011.49

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