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Article

Mechanism and effect of thrombospondin-4 polymorphisms on neutrophil function.

Blood - 1 Dec 2005

Pluskota Elzbieta, Stenina Olga I, Krukovets Irene, Szpak Dorota, Topol Eric J, Plow Edward F

Abstract excerpt

High-throughput genomic technology identified an association between a single nucleotide polymorphism (SNP), a proline (P387) rather than the predominant alanine (A387) at position 387 in thrombospondin-4 (TSP-4) and premature myocardial infarction. The inflammatory hypothesis of atherosclerosis invokes a prominent role of leukocytes and cytokines in pathogenesis. As the expression of TSP-4 by vascular cells...

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Identifiers

PMID: 16099885
DOI: 10.1182/blood-2005-03-1292
PMCID: PMC1895095

Genes

EGF
STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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