Article
Estrogen, inflammation, and platelet phenotype.
Gender medicine - 1 Jan 2008
Miller Virginia M, Jayachandran Muthuvel, Hashimoto Kazumori, Heit John A, Owen Whyte G
Abstract excerpt
BACKGROUND: Although exogenous estrogenic therapies increase the risk of thrombosis, the effects of estrogen on formed elements of blood are uncertain. OBJECTIVE: This article examines the genomic and nongenomic actions of estrogen on platelet phenotype that may contribute to increased thrombotic risk. METHODS: To determine aggregation, secretion, protein expression, and thrombin generation, platelets were...
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