Article
Genome-wide investigation reveals pathogen-specific and shared signatures in the response of Caenorhabditis elegans to infection.
Genome biology - 1 Jan 2007
Wong Daniel, Bazopoulou Daphne, Pujol Nathalie, Tavernarakis Nektarios, Ewbank Jonathan J
Abstract excerpt
BACKGROUND: There are striking similarities between the innate immune systems of invertebrates and vertebrates. Caenorhabditis elegans is increasingly used as a model for the study of innate immunity. Evidence is accumulating that C. elegans mounts distinct responses to different pathogens, but the true extent of this specificity is unclear. Here, we employ direct comparative genomic analyses to explore the...
Topics
- Animals
- Bacterial Infections
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Gene Expression Profiling
- Gene Expression Regulation
- Genome
- Immune System
- Immunity
- Models, Biological