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Article

Identification of innate immunity genes and pathways using a comparative genomics approach.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 2008

Alper Scott, Laws Rebecca, Lackford Brad, Boyd Windy A, Dunlap Paul, Freedman Jonathan H, Schwartz David A

Abstract excerpt

To reveal regulators of innate immunity, we used RNAi assays to monitor the immune response when genes are inhibited in Caenorhabditis elegans and mouse macrophages. Genes that altered innate immune responsiveness in C. elegans were validated in murine macrophages, resulting in the discovery of 11 genes that regulate the innate immune response in both systems and the subsequent identification of a protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18463287
DOI: 10.1073/pnas.0802405105
PMCID: PMC2383967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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