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Article

p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.

PLoS genetics - 10 Nov 2006

Troemel Emily R, Chu Stephanie W, Reinke Valerie, Lee Siu Sylvia, Ausubel Frederick M, Kim Dennis H

Abstract excerpt

The PMK-1 p38 mitogen-activated protein kinase pathway and the DAF-2-DAF-16 insulin signaling pathway control Caenorhabditis elegans intestinal innate immunity. pmk-1 loss-of-function mutants have enhanced sensitivity to pathogens, while daf-2 loss-of-function mutants have enhanced resistance to...

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Identifiers

PMID: 17096597
DOI: 10.1371/journal.pgen.0020183
PMCID: PMC1635533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17096597-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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