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Article

The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.

Bioscience, biotechnology, and biochemistry - 24 Feb 2022

Tsuru Ayano, Hamazaki Yumi, Tomida Shuta, Ali Mohammad Shaokat, Kage-Nakadai Eriko

Abstract excerpt

Cutibacterium acnes plays roles in both acne disease and healthy skin ecosystem. We observed that mutations in the tir-1/SARM1 and p38 MAPK cascade genes significantly shortened Caenorhabditis elegans lifespan upon C. acnes SK137 infection. Antimicrobial molecules were induced by SK137 in a TIR-1-dependent manner. These results suggest that defense responses against SK137 involve the TIR-1-p38 MAPK pathway in C....

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Identifiers

PMID: 34919641
DOI: 10.1093/bbb/zbab218
PMCID: PMC8866249

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