Article
MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells.
The EMBO journal - 16 Oct 2000
Garrington T P, Ishizuka T, Papst P J, Chayama K, Webb S, Yujiri T, Sun W, Sather S, Russell D M, Gibson S B, Keller G, Gelfand E W, Johnson G L
Abstract excerpt
Ligation of the high-affinity IgE receptor (FcepsilonRI) or of c-Kit stimulates cytokine production in mast cells. We show that MEK kinase 2 (MEKK2), a MAPK kinase kinase (MAP3K) that regulates the JNK and ERK5 pathways, is required for cytokine production in embryonic stem (ES) cell-derived mast cells (ESMC). Targeted disruption of the MEKK2 or MEKK1 gene was used to abolish expression of the respective kinases...
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