Article
MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.
The Journal of biological chemistry - 16 Feb 2001
Sun W, Kesavan K, Schaefer B C, Garrington T P, Ware M, Johnson N L, Gelfand E W, Johnson G L
Abstract excerpt
MEKK2 and MEKK3 are two closely related mitogen-activated protein kinase (MAPK) kinase kinases. The kinase domains of MEKK2 and MEKK3 are nearly identical, although their N-terminal regulatory domains are significantly divergent. By yeast two-hybrid library screening, we have identified MEK5, the MAPK kinase in the big mitogen-activated protein kinase 1 (BMK1)/ERK5 pathway, as a binding partner for MEKK2. MEKK2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.