Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple Regulatory Domains of IRF-5 Control Activation, Cellular Localization, and Induction of Chemokines That Mediate Recruitment of T Lymphocytes

28 Jul 2002

Abstract excerpt

Transcription factors of the interferon regulatory factor (IRF) family have been identified as critical mediators of early inflammatory gene transcription in infected cells. We recently determined that, besides IRF-3 and IRF-7, IRF-5 serves as a direct transducer of virus-mediated signaling. In contrast to that mediated by the other two IRFs, IRF-5-mediated activation is virus specific. We show that, in addition...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to interferon and immune responses
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12138184
DOI: 10.1128/mcb.22.16.5721-5740.2002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple Regulatory Domains of IRF-5 Control Activation, Cellular Localization, and Induction of Chemokines That Mediate Recruitment of T LymphocytesPMID 12138184Read ↗

A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.Semantic proximity Read ↗

Functional Characterization of Murine Interferon Regulatory Factor 5 (IRF-5) and Its Role in the Innate Antiviral ResponseSemantic proximity Read ↗

IRF5-mediated immune responses and its implications in immunological disordersSemantic proximity Read ↗

Global and Distinct Targets of IRF-5 and IRF-7 during Innate Response to Viral InfectionSemantic proximity Read ↗

Advances and challenges in targeting IRF5, a key regulator of inflammationSemantic proximity Read ↗

Non-transcriptional IRF7 interacts with NF-κB to inhibit viral inflammation.Semantic proximity Read ↗

Regulation and role of the transcription factor IRF5 in innate immune responses and systemic lupus erythematosusSemantic proximity Read ↗

Differential Requirement of Histone Acetylase and Deacetylase Activities for IRF5-Mediated Proinflammatory Cytokine ExpressionSemantic proximity Read ↗

Essential role of interferon regulatory factor 3 in direct activation of RANTES chemokine transcription.Semantic proximity Read ↗

IRF5-mediated signaling and implications for SLE.Semantic proximity Read ↗

Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection.Semantic proximity Read ↗

The Molecular Basis of Viral Inhibition of IRF- and STAT-Dependent Immune ResponsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.