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Article

Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection.

Journal of virology - 1 Oct 2014

Thackray Larissa B, Shrestha Bimmi, Richner Justin M, Miner Jonathan J, Pinto Amelia K, Lazear Helen M, Gale Michael, Diamond Michael S

Abstract excerpt

UNLABELLED: Upon activation of Toll-like and RIG-I-like receptor signaling pathways, the transcription factor IRF5 translocates to the nucleus and induces antiviral immune programs. The recent discovery of a homozygous mutation in the immunoregulatory gene guanine exchange factor dedicator of cytokinesis 2 (Dock2mu/mu) in several Irf5-/- mouse colonies has complicated interpretation of immune functions previously...

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Source

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Identifiers

PMID: 25031348
DOI: 10.1128/JVI.01545-14
PMCID: PMC4178807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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