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Article

The Molecular Basis of Viral Inhibition of IRF- and STAT-Dependent Immune Responses

8 Jan 2019

Abstract excerpt

The antiviral innate immunity is the first line of host defense against virus infections. In mammalian cells, viral infections initiate the expression of interferons (IFNs) in the host that in turn activate an antiviral defense program to restrict viral replications by induction of IFN stimulated genes (ISGs), which are largely regulated by the IFN-regulatory factor (IRF) family and signal transducer and...

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Identifiers

PMID: 30671058
DOI: 10.3389/fimmu.2018.03086

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