Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circadian differences in behavioral sensitization to cocaine: putative role of arylalkylamine N-acetyltransferase.

Life sciences - 10 May 2002

Uz Tolga, Javaid Javaid I, Manev Hari

Abstract excerpt

Circadian rhythms might be involved in addictive behaviors. The pineal secretory product melatonin decreases cocaine sensitization in rats; mice mutant for the critical melatonin-synthesizing enzyme, arylalkylamine N-acetyltransferase (AANAT), exhibit altered behaviors. We hypothesized that AANAT/melatonin system, which is up-regulated at night, affects cocaine sensitization in mice. Intraperitoneal cocaine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arylamine N-Acetyltransferase
Share to Behavior, Addictive
Share to Circadian Rhythm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cocaine

Share to Cocaine-Related Disorders

Share to Drug Tolerance

Share to Mice, Inbred C3H

Share to Motor Activity

Source

Identifiers

PMID: 12138020
DOI: 10.1016/s0024-3205(02)01559-x

Genes

AANAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circadian differences in behavioral sensitization to cocaine: putative role of arylalkylamine N-acetyltransferase.PMID 12138020Read ↗

A congenic line of the C57BL/6J mouse strain that is proficient in melatonin synthesis.Semantic proximity Read ↗

Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway.Semantic proximity Read ↗

Protracted 'anti-addictive' effects of adolescent phenylpropanolamine exposure in C57BL/6J mice.Semantic proximity Read ↗

Protracted 'pro-addictive' phenotype produced in mice by pre-adolescent phenylpropanolamine.Semantic proximity Read ↗

Circadian rhythms and addiction: mechanistic insights and future directions.Semantic proximity Read ↗

Circadian-Dependent and Sex-Dependent Increases in Intravenous Cocaine Self-Administration in Npas2 Mutant Mice.Semantic proximity Read ↗

Requirement of circadian genes for cocaine sensitization in Drosophila.Semantic proximity Read ↗

The Circadian System Is a Target and Modulator of Prenatal Cocaine EffectsSemantic proximity Read ↗

Rodent Aanat: intronic E-box sequences control tissue specificity but not rhythmic expression in the pineal gland.Semantic proximity Read ↗

Acute sensitivity vs. context-specific sensitization to cocaine as a function of genotype.Semantic proximity Read ↗

Melatonin is required for the circadian regulation of sleep.Semantic proximity Read ↗

alpha(2A)-Adrenoceptors regulate d-amphetamine-induced hyperactivity and behavioural sensitization in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.