Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protracted 'pro-addictive' phenotype produced in mice by pre-adolescent phenylpropanolamine.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2007

Szumlinski Karen K, Liu Andrew, Penzner Jeffery H, Lominac Kevin D

Abstract excerpt

For decades, the sympathomimetic phenylpropanolamine (PPA; +/- -norepinephrine) was an active ingredient found in popular children's over-the-counter (OTC) cold, cough, and allergy medications. To examine the possibility that pre-adolescent PPA exposure may induce neuroadaptations that influence behavioral and neurochemical responding to cocaine, C57BL/6J mice were pretreated with PPA (0-40 mg/kg) during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biogenic Monoamines
Share to Cocaine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cocaine-Related Disorders

Share to Conditioning, Operant

Share to Dopamine Uptake Inhibitors

Share to Drug Interactions

Share to Nucleus Accumbens

Share to Stereotyped Behavior

Source

Identifiers

PMID: 17251912
DOI: 10.1038/sj.npp.1301306

Genes

OTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protracted 'pro-addictive' phenotype produced in mice by pre-adolescent phenylpropanolamine.PMID 17251912Read ↗

Protracted 'anti-addictive' effects of adolescent phenylpropanolamine exposure in C57BL/6J mice.Semantic proximity Read ↗

Reward-centricity and attenuated aversions: An adolescent phenotype emerging from studies in laboratory animals.Semantic proximity Read ↗

Adolescent and adult responsiveness to the incentive value of cocaine reward in mice: role of neuronal nitric oxide synthase (nNOS) gene.Semantic proximity Read ↗

Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine.Semantic proximity Read ↗

Adolescence: a time of transition for the phenotype of dcc heterozygous mice.Semantic proximity Read ↗

Neurobiological contributions to addiction: a narrative review of adolescent and adult vulnerabilities.Semantic proximity Read ↗

Deletion of the 5-HT(3A)-receptor subunit blunts the induction of cocaine sensitization.Semantic proximity Read ↗

Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice.Semantic proximity Read ↗

Evidence of long-term expression of behavioral sensitization to both cocaine and ethanol in dopamine transporter knockout mice.Semantic proximity Read ↗

Cocaine during adolescence differentially impacts psychomotor sensitization and epigenetic profiles in adult male rats with divergent affective phenotypesSemantic proximity Read ↗

Acute sensitivity vs. context-specific sensitization to cocaine as a function of genotype.Semantic proximity Read ↗

Sensitivity to cocaine in adult mice is due to interplay between genetic makeup, early environment and later experience.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.