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Article

alpha(2A)-Adrenoceptors regulate d-amphetamine-induced hyperactivity and behavioural sensitization in mice.

European journal of pharmacology - 4 Jul 2005

Juhila Juuso, Honkanen Aapo, Sallinen Jukka, Haapalinna Antti, Korpi Esa R, Scheinin Mika

Abstract excerpt

Stimulants, such as d-amphetamine, enhance the release of dopamine in the central nervous system (CNS) and induce locomotor activation in mice. When amphetamine is administered repeatedly, the locomotor activation is progressively increased. This behavioural sensitization may be associated with the development of drug craving, addiction and dependence. Also noradrenergic mechanisms participate in the mediation of...

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Identifiers

PMID: 15978573
DOI: 10.1016/j.ejphar.2005.05.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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