Article
Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway.
Proceedings of the National Academy of Sciences of the United States of America - 4 May 2010
Shimomura Kazuhiro, Lowrey Phillip L, Vitaterna Martha Hotz, Buhr Ethan D, Kumar Vivek, Hanna Peter, Omura Chiaki, Izumo Mariko, Low Sharon S, Barrett R Keith, LaRue Silvia I, Green Carla B, Takahashi Joseph S
Abstract excerpt
Most laboratory mouse strains including C57BL/6J do not produce detectable levels of pineal melatonin owing to deficits in enzymatic activity of arylalkylamine N-acetyltransferase (AANAT) and N-acetylserotonin O-methyl transferase (ASMT), two enzymes necessary for melatonin biosynthesis. Here we report that alleles segregating at these two loci in C3H/HeJ mice, an inbred strain producing melatonin, suppress the...
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