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Article

Protracted 'anti-addictive' effects of adolescent phenylpropanolamine exposure in C57BL/6J mice.

Addiction biology - 1 Sept 2008

Penzner Jeffery H, Thompson Daria L, Arth Cory, Fowler Jaclyn K, Ary Alexis W, Szumlinski Karen K

Abstract excerpt

Exposure to the once highly prevalent over-the-counter (OTC) sympathomimetic phenylpropanolamine (PPA; +/--norephedrine) during pre-adolescence alters the developmental trajectory of catecholamine and amino acid neurotransmitter systems in the nucleus accumbens (NAC) that culminate in a 'pro-addictive' phenotype in adulthood. Thus, the present study sought to extend these earlier data by examining the long-term...

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Source

Identifiers

PMID: 18331369
DOI: 10.1111/j.1369-1600.2008.00101.x

Genes

OTC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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