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Article

Circadian-Dependent and Sex-Dependent Increases in Intravenous Cocaine Self-Administration in Npas2 Mutant Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Feb 2021

DePoy Lauren M, Becker-Krail Darius D, Zong Wei, Petersen Kaitlyn, Shah Neha M, Brandon Jessica H, Miguelino Alyssa M, Tseng George C, Logan Ryan W, McClung Colleen A

Abstract excerpt

Substance use disorder (SUD) is associated with disruptions in circadian rhythms. The circadian transcription factor neuronal PAS domain protein 2 (NPAS2) is enriched in reward-related brain regions and regulates reward, but its role in SU is unclear. To examine the role of NPAS2 in drug taking, we measured intravenous cocaine self-administration (acquisition, dose-response, progressive ratio, extinction,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33268545
DOI: 10.1523/JNEUROSCI.1830-20.2020
PMCID: PMC7880289

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