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Article

Requirement of circadian genes for cocaine sensitization in Drosophila.

Science (New York, N.Y.) - 13 Aug 1999

Andretic R, Chaney S, Hirsh J

Abstract excerpt

The circadian clock consists of a feedback loop in which clock genes are rhythmically expressed, giving rise to cycling levels of RNA and proteins. Four of the five circadian genes identified to date influence responsiveness to freebase cocaine in the fruit fly, Drosophila melanogaster. Sensitization to repeated cocaine exposures, a phenomenon also seen in humans and animal models and associated with enhanced...

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Identifiers

PMID: 10446052
DOI: 10.1126/science.285.5430.1066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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