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Article

A congenic line of the C57BL/6J mouse strain that is proficient in melatonin synthesis.

Journal of pineal research - 1 Oct 2018

Zhang Zhijing, Silveyra Eduardo, Jin Nange, Ribelayga Christophe P

Abstract excerpt

The C57BL/6J (B6) is the most common inbred mouse strain used in biomedical research in the United States. Yet, this strain is notoriously known for being deficient in the biosynthesis of melatonin, an important effector of circadian clocks in the brain and in the retina. Melatonin deficiency in this strain results from nonfunctional alleles of the genes coding 2 key enzymes of the melatonin synthesis pathway:...

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Identifiers

PMID: 29768727
DOI: 10.1111/jpi.12509
PMCID: PMC6167157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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