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Article

Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder.

Journal of psychiatry & neuroscience : JPN - 1 Jan 2009

Furmark Tomas, Henningsson Susanne, Appel Lieuwe, Ahs Fredrik, Linnman Clas, Pissiota Anna, Faria Vanda, Oreland Lars, Bani Massimo, Pich Emilio Merlo, Eriksson Elias, Fredrikson Mats

Abstract excerpt

BACKGROUND: Although the amygdala is thought to be a crucial brain region for negative affect, neuroimaging studies do not always show enhanced amygdala response to aversive stimuli in patients with anxiety disorders. Serotonin (5-HT)-related genotypes may contribute to interindividual variability in amygdala responsiveness. The short (s) allele of the 5-HT transporter linked polymorphic region (5-HTTLPR) and the...

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Identifiers

PMID: 19125211
PMCID: PMC2612081

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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