Article
A susceptibility gene for affective disorders and the response of the human amygdala.
Archives of general psychiatry - 1 Feb 2005
Hariri Ahmad R, Drabant Emily M, Munoz Karen E, Kolachana Bhaskar S, Mattay Venkata S, Egan Michael F, Weinberger Daniel R
Abstract excerpt
BACKGROUND: A common regulatory variant (5-HTTLPR) in the human serotonin transporter gene (SLC6A4), resulting in altered transcription and transporter availability, has been associated with vulnerability for affective disorders, including anxiety and depression. A recent functional magnetic resonance imaging study suggested that this association may be mediated by 5-HTTLPR effects on the response bias of the...
Topics
- Adult
- Amygdala
- Anger
- Emotions
- Facial Expression
- Fear
- Female
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Humans