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Article

Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders.

Journal of neuropathology and experimental neurology - 1 Jul 2002

Gu Guangyu, Reyes Patricio E, Golden Gregory T, Woltjer Randall L, Hulette Christine, Montine Thomas J, Zhang Jing

Abstract excerpt

Inhibition of mitochondrial respiratory chain function may contribute to dopaminergic neurodegeneration in the substantia nigra (SN) of patients with Parkinson disease (PD). Since large-scale structural changes (e.g. deletions and rearrangements in mitochondrial DNA [mtDNA]) have been associated with mitochondrial dysfunction, we tested the hypothesis that increased total mtDNA deletions/rearrangements are...

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Source

Identifiers

PMID: 12125742
DOI: 10.1093/jnen/61.7.634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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