Article
Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease.
Annals of neurology - 1 Jun 2012
Lin Michael T, Cantuti-Castelvetri Ippolita, Zheng Kangni, Jackson Katie E, Tan Yong B, Arzberger Thomas, Lees Andrew J, Betensky Rebecca A, Beal M Flint, Simon David K
Abstract excerpt
Somatic mutations in mitochondrial DNA (mtDNA) are hypothesized to play a role in Parkinson disease (PD), but large increases in mtDNA mutations have not previously been found in PD, potentially because neurons with high mutation levels degenerate and thus are absent in late stage tissue. To address this issue, we studied early stage PD cases and cases of incidental Lewy body disease (ILBD), which is thought to...
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