[Mitochondrial DNA and Parkinson disease. Methodologic review].

Article

[Mitochondrial DNA and Parkinson disease. Methodologic review].

Archives d'anatomie et de cytologie pathologiques - 1 Jan 1998

Pautot V, Macaigne C, Chariot P

Abstract excerpt

UNLABELLED: Parkinson's disease (PD), a disorder of unknown etiology, is associated with the degeneration of dopaminergic neurons in nigro-striatal pathways. MPTP, a meperidine analog, causes parkinsonism in human and nonhuman primates. MPP+, the active metabolite of MPTP, inhibits the activity o...

Topics

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Brain
DNA, Mitochondrial
Humans
MEDLINE
Mutation
National Library of Medicine (U.S.)
Parkinson Disease
Parkinson Disease, Secondary
Primates
United States

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.