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Article

[Mitochondrial DNA and Parkinson disease. Methodologic review].

Archives d'anatomie et de cytologie pathologiques - 1 Jan 1998

Pautot V, Macaigne C, Chariot P

Abstract excerpt

UNLABELLED: Parkinson's disease (PD), a disorder of unknown etiology, is associated with the degeneration of dopaminergic neurons in nigro-striatal pathways. MPTP, a meperidine analog, causes parkinsonism in human and nonhuman primates. MPP+, the active metabolite of MPTP, inhibits the activity of respiratory chain complex I. In patients with PD, a reduced complex I activity was found in substantia nigra,...

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PMID: 9754389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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