Article
Sequence analysis of the entire mitochondrial genome in Parkinson's disease.
Biochemical and biophysical research communications - 8 Feb 2002
Vives-Bauza Cristofol, Andreu Antoni L, Manfredi Giovanni, Beal M Flint, Janetzky Bernd, Gruenewald Thomas H, Lin Michael T
Abstract excerpt
The pathogenesis of Parkinson's disease (PD) is largely unknown. Indirect evidence suggests that mutations in mitochondrial DNA (mtDNA) might play a role, but previous studies have not consistently associated any specific mutations with PD. However, these studies have generally been confined to limited areas of the mitochondrial genome. We therefore sequenced the entire mitochondrial genome from substantia nigra...
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