Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence.

doi:10.1016/0006-291x(90)90497-b

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Article

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence.

Biochemical and biophysical research communications - 16 Aug 1990

Ikebe S, Tanaka M, Ohno K, Sato W, Hattori K, Kondo T, Mizuno Y, Ozawa T

Abstract excerpt

A mutant mitochondrial DNA (mtDNA) with a 4,977-bp deletion was detected in the parkinsonian brain by using the polymerase chain reaction. Although the deleted mtDNA was detectable even in the brain of aged controls, the proportion of deleted mtDNA to normal mtDNA in the striatum was higher in th...

Topics

Adult
Aged
Aging
Base Sequence
Corpus Striatum
DNA, Mitochondrial
Female
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Parkinson Disease
Polymerase Chain Reaction

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