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Evidence for polymerase gamma, POLG1 variation in reduced mitochondrial DNA copy number in Parkinson's disease.

Parkinsonism & related disorders - 1 Mar 2015

Gui Ya-Xing, Xu Zhong-Ping, Lv Wen, Zhao Jin-Jia, Hu Xing-Yue

Abstract excerpt

BACKGROUND: It remains unclear whether the mtDNA content is related to the clinicopathological prognosis in Parkinson's disease (PD). METHODS/RESULTS: We analyzed the copy number of mtDNA using quantitative real-time PCR in 414 cases with PD and 231 healthy subjects from mainland of China. The level of mtDNA was significantly decreased in PD patients' peripheral blood as compared to that of healthy controls (p <...

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Identifiers

PMID: 25585994
DOI: 10.1016/j.parkreldis.2014.12.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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