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Article

The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Jun 2013

Reeve Amy, Meagher Martin, Lax Nichola, Simcox Eve, Hepplewhite Philippa, Jaros Evelyn, Turnbull Doug

Abstract excerpt

Mitochondrial defects within substantia nigra (SN) neurons are implicated in the pathogenesis of Parkinson's disease. SN neurons show increased mitochondrial defects, mitochondrial DNA deletion levels, and susceptibility to such dysfunction, although the role of mitochondria in neuronal degeneration remains uncertain. In this study, we addressed this important question by exploring changes within the mitochondria...

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Source

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Identifiers

PMID: 23804100
DOI: 10.1523/JNEUROSCI.3525-12.2013
PMCID: PMC6618501

Genes

POLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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