Article
Evidence of selective sweeps in genes conferring resistance to chloroquine and pyrimethamine in Plasmodium falciparum isolates in India.
Antimicrobial agents and chemotherapy - 1 Mar 2010
Mixson-Hayden Tonya, Jain Vidhan, McCollum Andrea M, Poe Amanda, Nagpal Avinash C, Dash Aditya P, Stiles Jonathan K, Udhayakumar Venkatachalam, Singh Neeru
Abstract excerpt
Treatment of Plasmodium falciparum is complicated by the emergence and spread of parasite resistance to many of the first-line drugs used to treat malaria. Antimalarial drug resistance has been associated with specific point mutations in several genes, suggesting that these single nucleotide poly...
Topics
- Animals
- Antimalarials
- Chloroquine
- Drug Resistance
- Genes, Protozoan
- Genotype
- Humans
- India
- Malaria, Cerebral
- Malaria, Falciparum
- Microsatellite Repeats
- Parasitic Sensitivity Tests
- Plasmodium falciparum
- Point Mutation