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Article

Role of receptor kinase in long-term desensitization of the cardiac muscarinic receptor-K+ channel system.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2002

Shui Z, Khan I A, Tsuga H, Dobrzynski H, Haga T, Henderson Z, Boyett M R

Abstract excerpt

Desensitization of the cardiac muscarinic K+ channel was studied in cultured neonatal rat atrial cells and in Chinese hamster ovary (CHO) cells transfected with muscarinic receptor (HM(2)), G protein-coupled inward rectifying K+ channels 1 and 4, and G protein-coupled receptor kinase 2. In atrial cells incubated in 10 microM carbachol for 24 h, channel activity in cell-attached patches was substantially reduced...

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Source

Identifiers

PMID: 12124232
DOI: 10.1152/ajpheart.00515.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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