Rapid desensitization of the TRH receptor and persistent desensitization of its constitutively active mutant.

doi:10.1038/sj.bjp.0703291

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Article

Rapid desensitization of the TRH receptor and persistent desensitization of its constitutively active mutant.

British journal of pharmacology - 1 May 2000

Zaltsman I, Grimberg H, Lupu-Meiri M, Lifschitz L, Oron Y

Abstract excerpt

We studied rapid desensitization of the thyrotropin-releasing hormone receptor (TRH-R) or the m1-muscarinic receptor (m1-R) to a short challenge of threshold TRH concentration and persistent desensitization due to constitutive activity of a mutant TRH-R. Xenopus oocytes expressing TRH-Rs and/or m1-Rs were challenged for 15 s with threshold concentrations of TRH ([TRH]) and then immediately with supraoptimal [TRH]...

Topics

Acetylcholine
Animals
Electrophysiology
Mutation
Oocytes
Protein Kinase C
Receptors, Muscarinic
Receptors, Thyrotropin-Releasing Hormone
Thyrotropin-Releasing Hormone
Xenopus laevis

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PMID: 10807668
DOI: 10.1038/sj.bjp.0703291
PMCID: PMC1572060

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