Prolonged desensitization of the human endothelin A receptor in Xenopus oocytes. Comparative studies with the human neurokinin A receptor.

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Article

Prolonged desensitization of the human endothelin A receptor in Xenopus oocytes. Comparative studies with the human neurokinin A receptor.

The Journal of biological chemistry - 15 Dec 1993

Cyr C R, Rudy B, Kris R M

Abstract excerpt

Human endothelin (ET) A receptor (hETAR) is a G-protein-mediated receptor that binds ET1 with high affinity and ET2 and ET3 with lower affinities. ET1 is the most potent endogenous vasoconstrictor known at this time. When expressed in Xenopus laevis oocytes, hETAR is rapidly desensitized after st...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cells, Cultured
Humans
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Oocytes
Receptor, Endothelin A
Receptors, Endothelin
Receptors, Neurokinin-2
Sequence Deletion
Xenopus laevis

Source

Open in PubMed

Identifiers

PMID: 8253720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8253720-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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