Article
Role of phosphorylation in desensitization of acetylcholine receptors expressed in Xenopus oocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 1994
Hoffman P W, Ravindran A, Huganir R L
Abstract excerpt
The nicotinic acetylcholine receptor (AChR) is a pentameric complex made up of four types of subunits in the stoichiometry alpha 2 beta gamma delta. These subunits have been shown to be differentially phosphorylated by cAMP-dependent protein kinase (PKA) protein kinase C, and a protein tyrosine kinase. A variety of studies have suggested that phosphorylation of the AChR in vitro and in vivo regulates the rate of...
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