Article
Role of phosphorylation in desensitization of acetylcholine receptors expressed in Xenopus oocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 1994
Hoffman P W, Ravindran A, Huganir R L
Abstract excerpt
The nicotinic acetylcholine receptor (AChR) is a pentameric complex made up of four types of subunits in the stoichiometry alpha 2 beta gamma delta. These subunits have been shown to be differentially phosphorylated by cAMP-dependent protein kinase (PKA) protein kinase C, and a protein tyrosine kinase. A variety of studies have suggested that phosphorylation of the AChR in vitro and in vivo regulates the rate of...
Topics
- Animals
- Base Sequence
- Cyclic AMP-Dependent Protein Kinases
- Electrophysiology
- Female
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Oligonucleotide Probes
- Oocytes
- Phosphorylation