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Article

Receptor-coupled regulation of K+ channel N-type inactivation.

Neurobiology (Budapest, Hungary) - 1 Jan 1998

Velasco I, Beck E J, Covarrubias M

Abstract excerpt

Phosphorylation of the inactivation gate of a K+ channel (Kv3.4) by protein kinase C (PKC) slows rapid N-type inactivation. To demonstrate that such an effect could occur under more physiological conditions, Kv3.4 and a metabotropic serotonin (5-HT) receptor were coexpressed in Xenopus oocytes. Application of 5-HT 10 microM to these oocytes produced two main effects: 1) Enhanced activity of endogenous...

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PMID: 9713829

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