Article
Small-colony mutants of Staphylococcus aureus allow selection of gyrase-mediated resistance to dual-target fluoroquinolones.
Antimicrobial agents and chemotherapy - 1 Aug 2002
Pan Xiao-Su, Hamlyn Penelope J, Talens-Visconti Raquel, Alovero Fabiana L, Manzo Ruben H, Fisher L Mark
Abstract excerpt
Fluoroquinolones acting equally through DNA gyrase and topoisomerase IV in vivo are considered desirable in requiring two target mutations for emergence of resistant bacteria. To investigate this idea, we have studied the response of Staphylococcus aureus RN4220 to stepwise challenge with sparfloxacin, a known dual-target agent, and with NSFQ-105, a more potent sulfanilyl fluoroquinolone that behaves similarly....
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