Article
Haem toxicity provides a competitive advantage to the clinically relevant Staphylococcus aureus small colony variant phenotype.
Microbiology (Reading, England) - 1 Apr 2021
Herrin Brittany E, Islam Shariful, Rentschler Kaitlin N, Pert Lauren H, Kopanski Stephanie P, Wakeman Catherine A
Abstract excerpt
Microorganisms encounter toxicities inside the host. Many pathogens exist as subpopulations to maximize survivability. Subpopulations of Staphylococcus aureus include antibiotic-tolerant small colony variants (SCVs). These mutants often emerge following antibiotic treatment but can be present in infections prior to antibiotic exposure. We hypothesize that haem toxicity in the host selects for...
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