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Article

p16INK4 is inactivated by extensive CpG methylation in human hepatocellular carcinoma

1 Feb 1999

Abstract excerpt

BACKGROUND & AIMS: The molecular status of the p16(INK4) tumor-suppressor gene has not been fully elucidated in hepatocellular carcinoma. The aim of this study was to clarify the mechanism that gives rise to inactivation of p16(INK4) in hepatocellular carcinoma. METHODS: The status of p16(INK4) was evaluated in 60 hepatocellular carcinomas by immunohistochemical staining, differential polymerase chain reaction,...

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PMID: 9922321
DOI: 10.1016/s0016-5085(99)70137-x

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